HSPMdb Accession No | HSPMDB001456 |
PMID | 28615625 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | Az |
IUPAC Name | 4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)imidazol-1-yl]methyl]benzamide |
SMILES | COc1ccc(cc1)c2nc(n(Cc3ccc(cc3)C(N)=O)c2c4ccc(OC)cc4)c5cc(cc(c5)C(F)(F)F)C(F)(F)F |
Class | Imidazole derivative |
IC50 (µM) | 3.7 |
Site of Interaction | Nucleotide binding domain |
Cellular assay | MTT viability assay |
Cellular Model | THP1 |
Disease | Cancer |