HSPMdb Accession NoHSPMDB001444
PMID28615625
TargetHsp70
HSP NameHsc70 (HSPA8)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound NameAz
IUPAC Name4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)imidazol-1-yl]methyl]benzamide
SMILESCOc1ccc(cc1)c2nc(n(Cc3ccc(cc3)C(N)=O)c2c4ccc(OC)cc4)c5cc(cc(c5)C(F)(F)F)C(F)(F)F
ClassPiperidine derivative
IC50 (µM)2.8
Site of InteractionNucleotide binding domain
Cellular assayMTT viability assay
Cellular ModelHL60
DiseaseCancer

Structure



HSPMDB001444

Az

Physicochemical Properties