HSPMdb Accession NoHSPMDB001435
PMID25935385
TargetHsp70
HSP NameDnaK:DnaJ
OrganismBacteria
LocalizationCytosol and membrane
Enzymatic activityInhibition of ATPase activity
Compound Name22
IUPAC Name4-(((1-((2-Chlorothiazol-5-yl)methyl)piperidin-4-yl)(methyl)amino)methyl) benzonitrile
SMILESCN(Cc1ccc(cc1)C#N)C2CCN(CC2)Cc3sc(Cl)nc3
ClassPiperidine derivative
% Enzymatic Inhibition/Fold Change11.28% at 200 uM
Site of InteractionNucleotide binding domain (allosteric site)
Type of Enzymatic AssayATPase assay
DiseaseBacterial infection

Structure



HSPMDB001435

22

Physicochemical Properties