HSPMdb Accession NoHSPMDB001424
PMID25935385
TargetHsp70
HSP NameHsp70
OrganismHuman
LocalizationCytosol
Enzymatic activityBinding affinity
Compound NameVER-155008
IUPAC Name4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxymethyl]benzonitrile
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12
ClassPiperidine derivative
Kd (µM)0.206
Site of InteractionNucleotide binding domain (allosteric site)
Type of Enzymatic AssaySurface plasmon resonance (SPR)
DiseaseCancer

Structure



HSPMDB001424

VER-155008

Physicochemical Properties