HSPMdb Accession NoHSPMDB001408
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name52
IUPAC NameN-(3,4-dichlorobenzyl)-1-(2-methoxypyrimidin-4-yl)-N-methylpiperidin-4-amine
SMILESCOc1nccc(n1)N2CCC(CC2)N(C)Cc3ccc(Cl)c(Cl)c3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition60.2 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelMDA-MB-453
DiseaseCancer

Structure



HSPMDB001408

52

Physicochemical Properties