HSPMdb Accession NoHSPMDB001393
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name37
IUPAC NameN-(2-chloro-6-fluorobenzyl)-N-methyl-1-(2-(methylthio)pyrimidin-4-yl)piperidin-4-amine
SMILESCSc1nccc(n1)N2CCC(CC2)N(C)Cc3c(F)cccc3Cl
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition84.2 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelMDA-MB-453
DiseaseCancer

Structure



HSPMDB001393

37

Physicochemical Properties