HSPMdb Accession NoHSPMDB001387
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name31
IUPAC Name1-((2-Chlorothiazol-5-yl)methyl)-N-(2,6-dichlorobenzyl)-N-methylpiperidin-4-amine
SMILESCN(Cc1c(Cl)cccc1Cl)C2CCN(CC2)Cc3sc(Cl)nc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition72.4 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelMDA-MB-453
DiseaseCancer

Structure



HSPMDB001387

31

Physicochemical Properties