HSPMdb Accession NoHSPMDB001383
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name27
IUPAC Name1-((2-Chlorothiazol-5-yl)methyl)-N-(2,4-dichlorobenzyl)-N-methylpiperidin-4-amine
SMILESCN(Cc1ccc(Cl)cc1Cl)C2CCN(CC2)Cc3sc(Cl)nc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition60.8 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelMDA-MB-453
DiseaseCancer

Structure



HSPMDB001383

27

Physicochemical Properties