| HSPMdb Accession No | HSPMDB001356 |
| PMID | 25935385 |
| Target | Hsp70 |
| HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
| Organism | Human |
| Localization | Cytosol and nucleus |
| Cellular activity | Antiproliferative activity |
| Compound Name | Lapatinib |
| IUPAC Name | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine |
| SMILES | CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl |
| Class | Piperidine derivative |
| Site of Interaction | Nucleotide binding domain (allosteric site) |
| Percentage Cell Growth Inhibition | 42.6 at 5 uM |
| Cellular assay | Luminescence based viability assay |
| Cellular Model | MDA-MB-453 |
| Disease | Cancer |
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