HSPMdb Accession NoHSPMDB001346
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name58
IUPAC Name1-(6-Methoxypyrimidin-4-yl)-N-methyl-N-(4-methylbenzyl)piperidin-4-amine
SMILESCOc1cc(ncn1)N2CCC(CC2)N(C)Cc3ccc(C)cc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition22 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelSK/ LapR1.0
DiseaseCancer

Structure



HSPMDB001346

58

Physicochemical Properties