HSPMdb Accession NoHSPMDB001344
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name56
IUPAC NameN-(4-fluorobenzyl)-1-(2-methoxypyrimidin-4-yl)-N-methylpiperidin-4-amine
SMILESCOc1nccc(n1)N2CCC(CC2)N(C)Cc3ccc(F)cc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition9 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelSK/ LapR1.0
DiseaseCancer

Structure



HSPMDB001344

56

Physicochemical Properties