HSPMdb Accession NoHSPMDB001337
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name49
IUPAC Name2-(((1-(2-Methoxypyrimidin-4-yl)piperidin-4-yl)(methyl)amino)methyl) benzonitrile
SMILESCOc1nccc(n1)N2CCC(CC2)N(C)Cc3ccccc3C#N
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition74.3 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelSK/ LapR1.0
DiseaseCancer

Structure



HSPMDB001337

49

Physicochemical Properties