HSPMdb Accession No | HSPMDB001330 |
PMID | 25935385 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 42 |
IUPAC Name | N-methyl-N-(4-methylbenzyl)-1-(2-(methylthio)pyrimidin-4-yl)piperidin-4-amine |
SMILES | CSc1nccc(n1)N2CCC(CC2)N(C)Cc3ccc(C)cc3 |
Class | Piperidine derivative |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Percentage Cell Growth Inhibition | 42 at 5 uM |
Cellular assay | Luminescence based viability assay |
Cellular Model | SK/ LapR1.0 |
Disease | Cancer |