HSPMdb Accession NoHSPMDB001321
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name33
IUPAC Name1-((2-Chlorothiazol-5-yl)methyl)-N-(4-fluorobenzyl)piperidin-4-amine
SMILESFc1ccc(CNC2CCN(CC2)Cc3sc(Cl)nc3)cc1
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition40.4 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelSK/ LapR1.0
DiseaseCancer

Structure



HSPMDB001321

33

Physicochemical Properties