HSPMdb Accession No | HSPMDB001285 |
PMID | 25935385 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 65 |
IUPAC Name | 4-(((1-(6-Methoxypyrimidin-4-yl)piperidin-4-yl)(methyl)amino)methyl) benzonitrile |
SMILES | COc1cc(ncn1)N2CCC(CC2)N(C)Cc3ccc(cc3)C#N |
Class | Piperidine derivative |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Percentage Cell Growth Inhibition | 17.3 at 5 uM |
Cellular assay | Luminescence based viability assay |
Cellular Model | SK-BR-3 |
Disease | Cancer |