HSPMdb Accession NoHSPMDB001262
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name42
IUPAC NameN-methyl-N-(4-methylbenzyl)-1-(2-(methylthio)pyrimidin-4-yl)piperidin-4-amine
SMILESCSc1nccc(n1)N2CCC(CC2)N(C)Cc3ccc(C)cc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition38.9 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelSK-BR-3
DiseaseCancer

Structure



HSPMDB001262

42

Physicochemical Properties