HSPMdb Accession No | HSPMDB001257 |
PMID | 25935385 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 37 |
IUPAC Name | N-(2-chloro-6-fluorobenzyl)-N-methyl-1-(2-(methylthio)pyrimidin-4-yl)piperidin-4-amine |
SMILES | CSc1nccc(n1)N2CCC(CC2)N(C)Cc3c(F)cccc3Cl |
Class | Piperidine derivative |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Percentage Cell Growth Inhibition | 78.9 at 5 uM |
Cellular assay | Luminescence based viability assay |
Cellular Model | SK-BR-3 |
Disease | Cancer |