HSPMdb Accession NoHSPMDB001254
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name34
IUPAC NameN-(3-chlorobenzyl)-1-((2-chlorothiazol-5-yl)methyl)piperidin-4-amine
SMILESClc1sc(CN2CCC(CC2)NCc3cccc(Cl)c3)cn1
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition17.9 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelSK-BR-3
DiseaseCancer

Structure



HSPMDB001254

34

Physicochemical Properties