HSPMdb Accession NoHSPMDB001246
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name26
IUPAC NameN-(2-chloro-6-fluorobenzyl)-1-((2-chlorothiazol-5-yl)methyl)-N-methylpiperidin-4-amine
SMILESCN(Cc1c(F)cccc1Cl)C2CCN(CC2)Cc3sc(Cl)nc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition9.8 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelSK-BR-3
DiseaseCancer

Structure



HSPMDB001246

26

Physicochemical Properties