HSPMdb Accession No | HSPMDB001236 |
PMID | 25935385 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 16 |
IUPAC Name | N-(3,4-dichlorobenzyl)-N-methyl-1-((2-(methylthio)thiazol-5-yl)methyl)piperidin-4-amine |
SMILES | CSc1sc(CN2CCC(CC2)N(C)Cc3ccc(Cl)c(Cl)c3)cn1 |
Class | Piperidine derivative |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Percentage Cell Growth Inhibition | 42.4 at 5 uM |
Cellular assay | Luminescence based viability assay |
Cellular Model | SK-BR-3 |
Disease | Cancer |