HSPMdb Accession NoHSPMDB001235
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name15
IUPAC NameN-(4-fluorobenzyl)-N-methyl-1-((2-(methylthio)thiazol-5-yl)methyl)piperidin-4-amine
SMILESCSc1sc(CN2CCC(CC2)N(C)Cc3ccc(F)cc3)cn1
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition40.9 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelSK-BR-3
DiseaseCancer

Structure



HSPMDB001235

15

Physicochemical Properties