HSPMdb Accession NoHSPMDB001223
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name3
IUPAC NameN-(3,4-dichlorobenzyl)-1-((2-ethoxythiazol-5-yl)methyl)-N-methylpiperidin-4-amine
SMILESCCOc1sc(CN2CCC(CC2)N(C)Cc3ccc(Cl)c(Cl)c3)cn1
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition41.2 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelSK-BR-3
DiseaseCancer

Structure



HSPMDB001223

3

Physicochemical Properties