HSPMdb Accession No | HSPMDB001199 |
PMID | 25935385 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 43 |
IUPAC Name | N-(2,6-dichlorobenzyl)-N-methyl-1-(2-(methylthio)pyrimidin-4-yl)piperidin-4-amine |
SMILES | CSc1nccc(n1)N2CCC(CC2)N(C)Cc3c(Cl)cccc3Cl |
Class | Piperidine derivative |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Percentage Cell Growth Inhibition | 53.2 at 5 uM |
Cellular assay | Luminescence based viability assay |
Cellular Model | MDA-MB-361 |
Disease | Cancer |