HSPMdb Accession NoHSPMDB001199
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name43
IUPAC NameN-(2,6-dichlorobenzyl)-N-methyl-1-(2-(methylthio)pyrimidin-4-yl)piperidin-4-amine
SMILESCSc1nccc(n1)N2CCC(CC2)N(C)Cc3c(Cl)cccc3Cl
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition53.2 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelMDA-MB-361
DiseaseCancer

Structure



HSPMDB001199

43

Physicochemical Properties