HSPMdb Accession No | HSPMDB001185 |
PMID | 25935385 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 33 |
IUPAC Name | 1-((2-Chlorothiazol-5-yl)methyl)-N-(4-fluorobenzyl)piperidin-4-amine |
SMILES | Fc1ccc(CNC2CCN(CC2)Cc3sc(Cl)nc3)cc1 |
Class | Piperidine derivative |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Percentage Cell Growth Inhibition | 36.3 at 5 uM |
Cellular assay | Luminescence based viability assay |
Cellular Model | MDA-MB-361 |
Disease | Cancer |