HSPMdb Accession NoHSPMDB001182
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name30
IUPAC Name1-((2-Chlorothiazol-5-yl)methyl)-N-(3-fluorobenzyl)-N-methylpiperidin-4-amine
SMILESCN(Cc1cccc(F)c1)C2CCN(CC2)Cc3sc(Cl)nc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition3.2 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelMDA-MB-361
DiseaseCancer

Structure



HSPMDB001182

30

Physicochemical Properties