HSPMdb Accession No | HSPMDB001181 |
PMID | 25935385 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 29 |
IUPAC Name | 1-((2-Chlorothiazol-5-yl)methyl)-N-methyl-N-(4-methylbenzyl)piperidin-4-amine |
SMILES | CN(Cc1ccc(C)cc1)C2CCN(CC2)Cc3sc(Cl)nc3 |
Class | Piperidine derivative |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Percentage Cell Growth Inhibition | 10.9 at 5 uM |
Cellular assay | Luminescence based viability assay |
Cellular Model | MDA-MB-361 |
Disease | Cancer |