HSPMdb Accession NoHSPMDB001162
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name10
IUPAC NameN-(2,5-dichlorobenzyl)-1-((2-ethoxythiazol-5-yl)methyl)-N-methylpiperidin-4-amine
SMILESCCOc1sc(CN2CCC(CC2)N(C)Cc3cc(Cl)ccc3Cl)cn1
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition25.3 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelMDA-MB-361
DiseaseCancer

Structure



HSPMDB001162

10

Physicochemical Properties