HSPMdb Accession NoHSPMDB001159
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name7
IUPAC Name1-((2-Ethoxythiazol-5-yl)methyl)-N-(4-fluorobenzyl)-N-methylpiperidin-4-amine
SMILESCCOc1sc(CN2CCC(CC2)N(C)Cc3ccc(F)cc3)cn1
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition24.2 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelMDA-MB-361
DiseaseCancer

Structure



HSPMDB001159

7

Physicochemical Properties