HSPMdb Accession NoHSPMDB001145
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name61
IUPAC NameN-(4-fluorobenzyl)-1-(6-methoxypyrimidin-4-yl)-N-methylpiperidin-4-amine
SMILESCOc1cc(ncn1)N2CCC(CC2)N(C)Cc3ccc(F)cc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition8.1 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT/LapR1.0
DiseaseCancer

Structure



HSPMDB001145

61

Physicochemical Properties