HSPMdb Accession NoHSPMDB001122
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name38
IUPAC NameN-(3,4-dichlorobenzyl)-N-methyl-1-(2-(methylthio)pyrimidin-4-yl)piperidin-4-amine
SMILESCSc1nccc(n1)N2CCC(CC2)N(C)Cc3ccc(Cl)c(Cl)c3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition29.9 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT/LapR1.0
DiseaseCancer

Structure



HSPMDB001122

38

Physicochemical Properties