HSPMdb Accession NoHSPMDB001116
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name32
IUPAC Name1-((2-Chlorothiazol-5-yl)methyl)-N-(3,4-dichlorobenzyl)piperidin-4-amine
SMILESClc1sc(CN2CCC(CC2)NCc3ccc(Cl)c(Cl)c3)cn1
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition10.6 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT/LapR1.0
DiseaseCancer

Structure



HSPMDB001116

32

Physicochemical Properties