HSPMdb Accession NoHSPMDB001112
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name28
IUPAC Name1-((2-Chlorothiazol-5-yl)methyl)-N-methyl-N-(2-methylbenzyl)piperidin-4-amine
SMILESCN(Cc1ccccc1C)C2CCN(CC2)Cc3sc(Cl)nc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition4 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT/LapR1.0
DiseaseCancer

Structure



HSPMDB001112

28

Physicochemical Properties