HSPMdb Accession NoHSPMDB001067
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name51
IUPAC NameN-(2,5-dichlorobenzyl)-1-(2-methoxypyrimidin-4-yl)-N-methylpiperidin-4-amine
SMILESCOc1nccc(n1)N2CCC(CC2)N(C)Cc3cc(Cl)ccc3Cl
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition27.5 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT474
DiseaseCancer

Structure



HSPMDB001067

51

Physicochemical Properties