HSPMdb Accession NoHSPMDB001045
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name29
IUPAC Name1-((2-Chlorothiazol-5-yl)methyl)-N-methyl-N-(4-methylbenzyl)piperidin-4-amine
SMILESCN(Cc1ccc(C)cc1)C2CCN(CC2)Cc3sc(Cl)nc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition14.2 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT474
DiseaseCancer

Structure



HSPMDB001045

29

Physicochemical Properties