HSPMdb Accession NoHSPMDB001040
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name24
IUPAC Name1-((2-Chlorothiazol-5-yl)methyl)-N-(3,4-dichlorobenzyl)-N-methylpiperidin-4-amine
SMILESCN(Cc1ccc(Cl)c(Cl)c1)C2CCN(CC2)Cc3sc(Cl)nc3
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition45.4 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT474
DiseaseCancer

Structure



HSPMDB001040

24

Physicochemical Properties