HSPMdb Accession NoHSPMDB001027
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name11
IUPAC NameN-methyl-N-(2-methylbenzyl)-1-((2-(methylthio)thiazol-5-yl)methyl)piperidin-4-amine
SMILESCSc1sc(CN2CCC(CC2)N(C)Cc3ccccc3C)cn1
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition15.5 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT474
DiseaseCancer

Structure



HSPMDB001027

11

Physicochemical Properties