HSPMdb Accession NoHSPMDB001020
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name4
IUPAC Name4-(((1-((2-Ethoxythiazol-5-yl)methyl)piperidin-4-yl)(methyl)amino)methyl) benzonitrile
SMILESCCOc1sc(CN2CCC(CC2)N(C)Cc3ccc(cc3)C#N)cn1
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition61.7 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT474
DiseaseCancer

Structure



HSPMDB001020

4

Physicochemical Properties