HSPMdb Accession NoHSPMDB001016
PMID25935385
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound NameLapatinib
IUPAC Name2-phenylethynesulfonamide
SMILESC1=CC=C(C=C1)C#CS(=O)(=O)N
ClassPiperidine derivative
Site of InteractionNucleotide binding domain (allosteric site)
Percentage Cell Growth Inhibition75.6 at 5 uM
Cellular assayLuminescence based viability assay
Cellular ModelBT474
DiseaseCancer

Structure



HSPMDB001016

Lapatinib

Physicochemical Properties