HSPMdb Accession No | HSPMDB001016 |
PMID | 25935385 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | Lapatinib |
IUPAC Name | 2-phenylethynesulfonamide |
SMILES | C1=CC=C(C=C1)C#CS(=O)(=O)N |
Class | Piperidine derivative |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Percentage Cell Growth Inhibition | 75.6 at 5 uM |
Cellular assay | Luminescence based viability assay |
Cellular Model | BT474 |
Disease | Cancer |