HSPMdb Accession No | HSPMDB001000 |
PMID | 24312699 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 22 |
IUPAC Name | 4-{[(2Z)-3-ethyl-5-[(2E)-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-4-oxo-1,3-thiazolidin-2-ylidene]methyl}-1-methylpyridin-1-ium chloride |
SMILES | [Cl-].CCN1\C(S\C(C1=O)=C1\SC2=CC=CC=C2N1C)=C\C1=CC=[N+](C)C=C1 |
Class | Rhodacyanine derivative |
EC50 (µM) | 19 |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Cellular assay | MTT viability assay |
Cellular Model | MCF7 |
Disease | Cancer |