HSPMdb Accession NoHSPMDB000997
PMID24312699
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name19
IUPAC Name2-{[(2Z)-3-ethyl-5-[(2E)-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-4-oxo-1,3-thiazolidin-2-ylidene]methyl}-1-propylpyridin-1-ium chloride
SMILES[Cl-].CCC[N+]1=C(\C=C2/S\C(C(=O)N2CC)=C2\SC3=CC=CC=C3N2C)C=CC=C1
Class Rhodacyanine derivative
EC50 (µM)2.8
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMCF7
DiseaseCancer

Structure



HSPMDB000997

19

Physicochemical Properties