HSPMdb Accession NoHSPMDB000996
PMID24312699
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name18
IUPAC Name2-{[(2Z)-3-benzyl-5-[(2E)-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-4-oxo-1,3-thiazolidin-2-ylidene]methyl}-1-methylpyridin-1-ium chloride
SMILES[Cl-].CN1\C(SC2=CC=CC=C12)=C1/S\C(=C/C2=[N+](C)C=CC=C2)N(CC2=CC=CC=C2)C1=O
Class Rhodacyanine derivative
EC50 (µM)2.9
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMCF7
DiseaseCancer

Structure



HSPMDB000996

18

Physicochemical Properties