HSPMdb Accession NoHSPMDB000972
PMID24312699
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name27(JG-83)
IUPAC Name3-benzyl-2-{[(2Z)-3-ethyl-5-[(2E)-4-fluoro-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-4-oxo-1,3-thiazolidin-2-ylidene]methyl}-1,3-thiazol-3-ium chloride
SMILES[Cl-].CCN1\C(S\C(C1=O)=C1\SC2=CC=CC(F)=C2N1C)=C\C1=[N+](CC2=CC=CC=C2)C=CS1
Class Rhodacyanine derivative
EC50 (µM)0.4
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMDA-MB-231
DiseaseCancer

Structure



HSPMDB000972

27(JG-83)

Physicochemical Properties