HSPMdb Accession No | HSPMDB000963 |
PMID | 24312699 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 18 |
IUPAC Name | 2-{[(2Z)-3-benzyl-5-[(2E)-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-4-oxo-1,3-thiazolidin-2-ylidene]methyl}-1-methylpyridin-1-ium chloride |
SMILES | [Cl-].CN1\C(SC2=CC=CC=C12)=C1/S\C(=C/C2=[N+](C)C=CC=C2)N(CC2=CC=CC=C2)C1=O |
Class | Rhodacyanine derivative |
EC50 (µM) | 1.8 |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Cellular assay | MTT viability assay |
Cellular Model | MDA-MB-231 |
Disease | Cancer |