HSPMdb Accession NoHSPMDB000962
PMID24312699
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name17
IUPAC Name1-methyl-2-{[(2Z)-5-[(2E)-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-4-oxo-3-(prop-2-en-1-yl)-1,3-thiazolidin-2-ylidene]methyl}pyridin-1-ium chloride
SMILES[Cl-].CN1\C(SC2=CC=CC=C12)=C1/S\C(=C/C2=[N+](C)C=CC=C2)N(CC=C)C1=O
Class Rhodacyanine derivative
EC50 (µM)3.6
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMDA-MB-231
DiseaseCancer

Structure



HSPMDB000962

17

Physicochemical Properties