HSPMdb Accession NoHSPMDB000943
PMID27035072
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name32
IUPAC Name1-(4-Carboxamidobenzyl)-2-(3,5-bis(trifluoromethyl)phenyl)-1H-imidazo[4,5-f][1,10]-phenanthroline
SMILESNC(=O)C1=CC=C(CN2C(=NC3=C2C2=C(N=CC=C2)C2=C3C=CC=N2)C2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C=C1
Class Phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthroline
GI50 (µM)2.5
Cellular assay Resazurin based viability assay
Cellular ModelWM266.4
DiseaseCancer

Structure



HSPMDB000943

32

Physicochemical Properties