HSPMdb Accession No | HSPMDB000932 |
PMID | 27035072 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 22 |
IUPAC Name | 1-(4-Carboxamidobenzyl)-2-(4-fluorophenyl)-1H-phenanthro-[9,10-d]imidazole |
SMILES | NC(=O)C1=CC=C(CN2C(=NC3=C2C2=C(C=CC=C2)C2=C3C=CC=C2)C2=CC=C(F)C=C2)C=C1 |
Class | Phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthroline |
GI50 (µM) | >10 |
Cellular assay | Resazurin based viability assay |
Cellular Model | MCF7 |
Disease | Cancer |