HSPMdb Accession NoHSPMDB000907
PMID27035072
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name6 (apoptozole)
IUPAC Name4-({2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl}methyl)benzamide
SMILESCOc1ccc(cc1)c2nc(n(Cc3ccc(cc3)C(N)=O)c2c4ccc(OC)cc4)c5cc(cc(c5)C(F)(F)F)C(F)(F)F
Class Phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthroline
GI50 (µM)7
Site of InteractionNucleotide binding domain
Cellular assay Resazurin based viability assay
Cellular ModelHCT116
DiseaseCancer

Structure



HSPMDB000907

6 (apoptozole)

Physicochemical Properties