HSPMdb Accession No | HSPMDB000907 |
PMID | 27035072 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 6 (apoptozole) |
IUPAC Name | 4-({2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl}methyl)benzamide |
SMILES | COc1ccc(cc1)c2nc(n(Cc3ccc(cc3)C(N)=O)c2c4ccc(OC)cc4)c5cc(cc(c5)C(F)(F)F)C(F)(F)F |
Class | Phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthroline |
GI50 (µM) | 7 |
Site of Interaction | Nucleotide binding domain |
Cellular assay | Resazurin based viability assay |
Cellular Model | HCT116 |
Disease | Cancer |