| HSPMdb Accession No | HSPMDB000904 |
| PMID | 24548239 |
| Target | Hsp70 |
| HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
| Organism | Human |
| Localization | Cytosol and nucleus |
| Cellular activity | Antiproliferative activity |
| Compound Name | 27f |
| IUPAC Name | N-(3-((4-(Benzyloxy)-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)-thio)phenyl)pyrrolidine-2-carboxamide |
| SMILES | CN1CCN(CC1)c2ncc(Sc3cccc(NC(=O)C4CCCN4)c3)c(OCc5ccccc5)n2 |
| Class | 2,5-Thiodipyrimidine and 5-(Phenylthio) pyrimidine acrylamide |
| GI50 (µM) | 2.9 |
| Site of Interaction | Nucleotide binding domain (allosteric site) |
| Cellular assay | Alamar Blue viability assay |
| Cellular Model | Kasumi-1 |
| Disease | Cancer |
Loading Please Wait ...