| HSPMdb Accession No | HSPMDB000886 |
| PMID | 24548239 |
| Target | Hsp70 |
| HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
| Organism | Human |
| Localization | Cytosol and nucleus |
| Cellular activity | Antiproliferative activity |
| Compound Name | 1b |
| IUPAC Name | N-(2-{[4,6-dimethoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]sulfanyl}pyrimidin-4-yl)prop-2-enamide |
| SMILES | COC1=NC(=NC(OC)=C1SC1=NC=CC(NC(=O)C=C)=N1)N1CCN(C)CC1 |
| Class | 2,5-Thiodipyrimidine and 5-(Phenylthio) pyrimidine acrylamide |
| GI50 (µM) | 1.25 |
| Site of Interaction | Nucleotide binding domain (allosteric site) |
| Cellular assay | Alamar Blue viability assay |
| Cellular Model | Kasumi-1 |
| Disease | Cancer |
Loading Please Wait ...