| HSPMdb Accession No | HSPMDB000885 |
| PMID | 24548239 |
| Target | Hsp70 |
| HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
| Organism | Human |
| Localization | Cytosol and nucleus |
| Cellular activity | Antiproliferative activity |
| Compound Name | 3a |
| IUPAC Name | N-(6-Amino-2-((4,6-diethoxy-2-(4-methylpiperazin-1-yl)-pyrimidin-5-yl)thio)pyrimidin-4-yl)propionamide |
| SMILES | NC1=CC(=NC(=N1)SC=1C(=NC(=NC1OCC)N1CCN(CC1)C)OCC)NC(CC)=O |
| Class | 2,5-Thiodipyrimidine and 5-(Phenylthio) pyrimidine acrylamide |
| GI50 (µM) | 51.4 |
| Site of Interaction | Nucleotide binding domain (allosteric site) |
| Cellular assay | Alamar Blue viability assay |
| Cellular Model | Kasumi-1 |
| Disease | Cancer |
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